CONCLUSIONS An extremely high CK activity in rhabdomyolysis may lead to AKI. High blood pressure happens when the force of the blood pushing on the walls of your arteries is too high. Methods. Physicians need to remain vigilant for cases of rhabdomyolysis that have not yet caused renal compromise. International Journal of Psychiatry in … Once the patient’s condition has been stabilized and life- and limb-threatening conditions have been addressed, he or she may be transferred to another facility if necessary. The most common of these antibodies are directed toward aminoacyl-tRNA synthetase activities. Muscle cells contain a variety of enzymes with particularly high concentrations of those involved in generating energy to power the muscles. 3. Ninety percent of patients who have polymyositis or dermatomyositis and are treated with corticosteroids achieve some clinical response; 50% to 75% achieve complete remission. Atlanta: Arthritis Foundation; 2008:375-380. This finding is common in patients who also have Raynaud phenomenon. Levels of creatinine kinase — a marker of muscle damage — are elevated in most amyotrophic lateral sclerosis (ALS) patients and appear to be significantly higher among those whose … His CK levels consistently trended down with treatment. Patients who carry these specific antibodies may present with certain clinical features and may not respond well to treatment, depending on the type of antibody present. 13. No single feature is diagnostic of an idiopathic inflammatory myopathy, and the diagnosis can be made only after the exclusion of other causes of these abnormalities. The weakness in patients with inclusion body myositis may develop even more insidiously over the course of years. Individual diseases included under the term “idiopathic inflammatory myopathy” are polymyositis and dermatomyositis, as well as myositis associated with neoplastic disease, myositis associated with collagen-vascular disease, and inclusion body myositis. Such levels clearly signal strong disturbance or … A 21-year-old male asked: do injured thighs, heart and chest have treatment also my creatine kinase is 412? 2009;(4):CD003643. Yo ... Read More. Obviously, I am hoping for 1 of the later 2. Nevertheless, one study showed significant reductions in creatinine levels in people with chronic kidney disease who increased their fiber intake. If your blood creatinine is high, it’s important to work with your healthcare provider to develop a treatment plan to address any medical issues that might be harming your kidney function. J Rheumatol. In examples of rhabdomyolysis (clinically diagnosed muscle damage) CK levels have been found at 10,000–200,000 U/L and as high as 3 × 1 0 6 U/L . CK or creatinine kinase is an enzyme specifically found in muscle cells. 44 years experience Pathology. The definition of normal CK levels in the blood varies by sex, race, and ethnicity. Women's History Month: Q&A with Rheumatologist Silvia Ross, M.D. Consider focusing on whole, unprocessed foods, and using spices and herbs to flavor your food when possible. Benefits, Uses, and How to Eat It, 10+ Tasty Low Carb or Keto Options at The Cheesecake Factory, Does Serrapeptase Work for Weight Loss? Smoking cigarettes can harm the body in a number of ways, including significantly increasing the risk of chronic kidney disease. If your healthcare provider finds that your creatinine levels are high, changes to your activity levels and eating, drinking, and supplementation habits may help reduce them. © 2021 MJH Life Sciences and Rheumatology Network. Solutions: drink more water and go to see the doctor. Treatment for High CPK Levels Usually, treatment for elevated CPK levels that are significantly higher than the normal CPK level range depends on treating the underlying cause. high creatine kinase treatment. 13th ed. Opt for the beta blocker treatment option for treating long-term higher levels of creatine kinase. 7. In addition, there can be normal individual and … Fluid intake can also be an issue for some people who have kidney disease. Aldolase is an alternative, being less specific for muscle injury than … Review of the literature. A 21-year-old male asked: do injured thighs, heart and chest have treatment also my creatine kinase is 412? What’s the Difference Between Kcal and Calories? © 2021 MJH Life Sciences™ and Rheumatology Network. The best way to lower your creatinine levels is to treat the underlying cause. Severe alcohol withdrawal, an infection of the lining of the heart and brain injury are also causes of elevated creatine kinase in the body. 2005;(3):CD003643. Clinical context: If you've had an injury to the muscle of your chest / thighs, you creatine kinase is likely to go way up -- even if it's just a deep muscle bruise. Bohan A, Peter JB, Bowman RL, Pearson CM. Weakness is a common clinical complaint that can be associated with significant morbidity. Therefore, a high CK level often suggests that the muscles themselves are the likely cause of the weakness, but it doesn’t tell exactly what the muscle disorder might be. The classic findings of muscle inflammation are seen in polymyositis, dermatomyositis, and inclusion body myositis. Physical examination The physician should assess all muscle groups, noting that the weakness in most idiopathic inflammatory myopathies is proximal (shoulder, neck, and pelvic girdle muscle) and symmetrical. Health conditions like blocked arteries, severe stress, and high blood pressure can put extra strain on your heart and cause damage to the muscle … There’s limited research on creatine supplements and their overall safety. T-cell infiltrates predominate, with CD8+ cytotoxic T cells most notably surrounding and invading muscle fibers. Other studies have shown that excessive alcohol has the potential to damage the kidneys. Causes of Elevated CK Enzyme. What is a creatine kinase (CK) test? Nutrition and Benefits, Grapefruit Seed Extract: Benefits, Myths, and Dangers. Evaluate success of treatment. Although elevated CK levels are seen in most cases of inflammatory myopathy, CK levels may be minimally elevated or even normal in inclusion body myositis, myositis associated with neoplasia, and early presentations of polymyositis and dermatomyositis and when significant muscle atrophy has developed. 1991;18:1693-1700. An elevated creatine kinase level may be caused by conditions such as a stroke, heart attack, trauma or muscle destruction, explains Healthgrades. Learn the difference and what these terms mean. Before medical therapy is started, a thorough assessment of a patient's individual muscle groups must be made so that his or her response to therapy may be measured objectively. When muscle cells are damaged for whatever reason, the CK enzyme is released into the blood. CK is a type of protein, known as an enzyme. High creatine kinase levels in blood test. Creatine is a natural compound made in your liver. Empirically, corticosteroids are used as first-line therapy to decrease inflammation. Patients with dermatomyositis have cutaneous findings that may precede or develop concomitantly with the muscle weakness or may develop after the onset of myopathy. Because the idiopathic inflammatory myopathies can overlap with neoplastic disease and collagen-vascular diseases (system lupus erythematosus, Sjgren syndrome, scleroderma, and mixed connective-tissue disease [MCTD]), a detailed review of systems looking for symptoms of these conditions should be performed. 2002;28:723-741. Low creatine kinase levels what does that mean. Symptoms may include muscle pains, weakness, vomiting, and confusion. High plasma CK, even in the normal range, may decrease the … Physiologically, when muscle contracts, ATP is converted to adenosine … High Creatinine Levels - Causes, Symptoms, Diets, Treatment 2019-01-30 16:26. 10. You may need a creatinine test if you have these symptoms: Your doctor may likewise recommend regular creatinine testing if you have any of the following conditions, which may contribute to decreased kidney function: Creatinine levels can also rise temporarily from strenuous exercise or using certain medications like sulfamethoxazole, trimethoprim, or chemotherapy drugs. A CT scan of the chest, abdomen, and pelvis and a thorough screening for age-appropriate cancer are recommended at the time of diagnosis. Talk with your healthcare provider about how much water and other fluids you should drink daily, as well as the best time to drink them. Avoiding Certain Medications Ask your doctor if statins are increasing your CPK counts. In many cases, medications can help resolve high creatinine levels by treating the condition that’s causing the increase. Quitting can be a way to reduce the likelihood of issues with your kidneys that may increase creatinine levels. Polymyositis and dermatomyositis (first of two parts). It aids in the production of phosphocreatine, a molecule utilized by your muscles for energy. Bohan A, Peter JB. One form of CPK is found in heart muscle cells, another in the skeletal muscle cells. Dr. Ed Friedlander answered. Results. 2) May Prevent Blood Clotting. Racial differences in serum creatine kinase levels. 12. Your healthcare provider may check your blood and urine for creatinine, as well as order other tests to evaluate the health of your kidneys. Such levels clearly signal strong disturbance or disintegration of striated muscle tissue with concomitant leakage of intracellular muscle constituents into the circulation. The muscle … Electromyography Electromyography is most useful for distinguishing between neuropathic and myopathic disease. The heat from cooking causes the creatine found in meat to produce creatinine. MRI findings of muscle edema or high CK levels generally differentiate a relapse of myositis from corticosteroid-induced myopathy. CK levels that are five times the upper limit of normal levels are considered to be evidence of rhabdomyolysis. Curr Opin Rheumatol. Filamentous, intracytoplasmic, or intranuclear inclusions may be visualized by electron microscopy. Skeletal muscles are the muscles attached to your skeleton. Although many complaints of weakness are purely subjective, the finding of objective muscle weakness indicates an underlying myopathic or neuropathic process. 2009;36:2704-2710. Update in: Cochrane Database Syst Rev. However, preserved kidney function is possible. Cochrane Database Syst Rev. Muscle biopsies from 2 patients showed focal necrosis and myopathic changes. Other diseases that may cause the insidious onset of muscle weakness include the muscular dystrophies, metabolic myopathies (glycogen and lipid storage diseases), and endocrine myopathies. What Is Barbary Fig? What's the Difference Between Pedialyte and Gatorade? For neonates, blood taken into a 0.8mL minicollect lithium heparin tube. The third step is to elicit any associated symptoms. Dr. Ed Friedlander answered. A recent systematic review highlighted the lack of quality studies assessing the efficacy and toxicity of various immunosuppressants in dermatomyositis and polymyositis.14 However, no medication has been found that alters the course of inclusion body myositis. CK levels do not necessarily correlate with disease activity. A doctor may also check for abnormal CPK levels if you have symptoms of cardiovascular disease. Treatment of high CPK, or creatine phosphokinase, levels involves treatment of the condition causing the elevation, according to Healthline. High creatine kinase treatment. Prednisone is the first-line treatment of choice for polymyositis. Cronin ME, Plotz PH. What is the treatment for elevated CPK? Literature has suggested that CK levels could rise in a period from 5 days to 2 years after initiation of antipsychotic treatment. Our website services, content, and products are for informational purposes only. Hydroxychloroquine, topical tacrolimus, and topical corticosteroids may be effective for cutaneous manifestations in patients with dermatomyositis13; however, they have no effect on the myositis. Over-the-counter painkillers like non-steroidal anti-inflammatory drugs (NSAIDs) may be harmful if taken too often or in amounts over the recommended dosage, especially if you have kidney disease. 5. Levels of CK and other muscle enzymes may be monitored during treatment; however, a decrease in these enzymes without any improvement in muscle weakness should not be mistaken for clinical improvement.10, Activity should be encouraged as soon as possible to prevent formation of muscle contractures. Creatine is a natural compound made in your liver. The acute onset of muscle weakness suggests a neuropathic or myopathic cause other than the idiopathic inflammatory myopathies. People following diets very high in red meat or other protein sources, including dairy products, may have higher creatinine levels than people who eat fewer of those foods. Patient 1 was a 59‐yr‐old man who was admitted with central chest pain. There may be tea-colored urine or an irregular heartbeat. high creatine kinase treatment. These patients also are more likely to have fever, arthritis, Raynaud phenomenon, and mechanic's hands. Description: Creatine kinase (CK) enzyme is found in heart and skeletal muscle and to a lesser extent brain. Some athletes use these creatinine-producing supplements to help enhance athletic performance. Less frequently seen are pulmonary (interstitial lung disease [ILD], diaphragmatic weakness) and cardiac manifestations (tachyarrhythmias, dilated cardiomyopathy). Alexanderson H, Lundberg IE. 2006;24:363-373. Creatine kinase. This article…. Optimized Treatment Strategies in Axial Spondyloarthritis: an Unmet Need. Work with your doctor or another health care professional to get an … The key pathophysiological events are volume depletion and aciduria, which should be corrected immediately … His ECGs and laboratory tests were normal apart from a raised creatine kinase (CK) of 600 IU/l. However, there is a certain limit as to how much of each of these enzymes should be present in … … However, preserved kidney function is possible. Rhabdomyolysis, a syndrome resulting from skeletal muscle injury, is characterized by muscle pain, weakness, myoglobinuria and elevated … Research shows that eating large amounts of protein can increase creatinine levels, at least temporarily. Prednisone should provide objective improvement in muscle weakness within 3 to 6 months. Creatinine is a waste product that’s generated when you use your muscles. Callen JP, Wortmann RL. Risk factors for a poor outcome include concomitant ILD, significant esophageal dysmotility, cardiomyopathy, malignancy, and anti-SRP antibodies. Lutikizumab Fails as Pain Treatment for Erosive Hand Osteoarthritis, The Journal of Musculoskeletal Medicine Vol 27 No 12. CK levels do not necessarily correlate with disease activity. The same association was found in another study of 454 overweight and obese people . With an estimated incidence of only 5 cases per million adults,1the idiopathic inflammatory myopathies are rare diseases. In severe cases, esophageal and pharyngeal muscle weakness can result in dysphagia, aspiration pneumonia, and dysphonia. What diseases would produce high ck levels? This article lists 10-plus low carb and keto at The…, Serrapeptase is an enzyme produced from the bacterium Serratia marcescens. CK levels that are five times the upper limit of normal levels are considered to be evidence of rhabdomyolysis. Since the heart is a muscle, an elevated CK level can mean that the heart is damaged as in a heart attack. Calories are a unit of energy, but in diet and exercise, the term is used to mean kilocalories (kcal). Diets that include excess salt can contribute to high blood pressure. Some of the muscle breakdown products, such as the protein myoglobin, are harmful to the kidneys and may lead to kidney failure.. TREATMENT Because the idiopathic inflammatory myopathies are relatively rare, referral to a specialist who is familiar with these diseases is recommended. This article reviews 16 healthy salty snacks. Rheum Dis Clin North Am. Physiologically, when muscle contracts, ATP is converted to adenosine diphosphate (ADP), and CK catalyzes the rephosphorylation of ADP to ATP using creatine phosphate as the phosphorylation reservoir. 14. Histochemical staining may show deposition of amyloid, ubiquitin, and SMI-31 in fibers. Inclusion body myositis is rare in patients younger than 60 years. Black HR, Quallich H, Gareleck CB. The scientists exposed overweight mice to either whole-body vibration or no treatment for six weeks. Generally, weakness begins insidiously over a period of 3 to 6 months, without a recognized precipitating event. Idiopathic inflammatory myopathy is a term applied to a group of relatively rare diseases that present with the gradual onset of weakness of shoulder and pelvic girdle muscles. Causes of High Creatine Kinase Levels. This article reviews Barbary fig, explores its uses and potential health benefits, and explains how you can add this fruit to your diet. CK is a type of protein, known as an enzyme. Statins are … A 21-year-old male asked: do injured thighs, heart and chest have treatment also my creatine kinase is 412? Additional features, including night sweats and muscle cramps, were noted after referral to the rheumatology department. 2005;17:164-171. Chapter C: Treatment and assessment. Creatine kinase levels in children. 2004;16:692-699. Elevated Muscle Enzymes Symptoms: Causes Of High Muscle Enzyme Levels The body produces a wide range of enzymes necessary for the processes in the body to run smoothly. The definition of normal CK levels in the blood varies by sex, race, and ethnicity. The examiner should assess the patient's ability to swallow and speak as well as the patient's cardiac and pulmonary function, because these muscles and organs also may be involved. This high creatine kinase levels can also give doctors an indication of the extent of muscle damage and recommend the best course of treatment. In summary, renal injury with high serum CPK values becomes a true concern when levels of CPK reach 5,000 IU/L and the patient has serious co-morbid disease such as volume depletion, sepsis or acidosis. I have found various causes for elevated CK levels-* Heart Issues * Muscular Diseases * Tyroid Problems * A Virus * Vitamin D or B12 Deficiencies. N Engl J Med. In general, very high CK levels are seen more frequently as a result of medications, trauma, aerobic and isometric exercises, and other causes of muscle injury. (2008). MRI with T2-weighted images and fat suppression, or STIR technique, can show edema in the muscle, which is indicative of inflammation.7 Because there often is only patchy involvement of the muscle, MRI is an effective noninvasive method for determining the optimal location for muscle biopsy. This test measures the amount of creatine kinase (CK) in the blood. Because of the association with ILD, patients with the anti-Jo-1 or other antisynthetase autoantibodies should receive baseline pulmonary function testing and a chest CT scan. 1. Medications: most notably statins used to treat high cholesterol (simvastatin [ Zocor ], atorvastatin [ Lipitor ], pravastatin [Pravachol], or lovastatin [ Mevacor ]) and other medications such … In this article, we describe an approach to the diagnosis and management of the idiopathic inflammatory myopathies. Although weakness progresses in an unrelenting fashion, it does so very slowly and is not associated with increased mortality. When muscle cells are damaged, these enzymes leak into the bloodstream and may causes elevated levels. His ECGs and laboratory tests were normal apart from a raised creatine kinase (CK) of 600 IU/l. The level of each of these proteins can be measured in blood to monitor the degree of muscle injury from rhabdomyolysis. 1977;56:255-286. It's … In contrast, neuropathic diseases typically present with distal or asymmetrical weakness and may present with abnormalities on neurological examination that would not be present in myopathic disease. In: Klippel JH, Stone JH, Crofford LJ, White PH, eds. Idiopathic inflammatory myopathies. To discuss the etiology, the clinical significance and the management of elevated creatine kinase levels in psychiatric in-patient practice, focusing on antipsychotic-induced rhabdomyolysis. Very high levels can be seen in all types of muscular dystrophy, crush injuries/rhabdomyolysis, burns, viral myositis, polymyositis, and other inflammatory myopathies. For adults, blood taken into a 5mL gold top tube (or rust top for the Acute Unit) For children, blood taken into a 3.5mL rust top tube. Your bloodstream transports creatinine to your kidneys, where your body filters it out through your urine. 6. Creatine kinase is a biomarker with good muscle specificity “Normal” values can vary depending on race and sex Several factors can elevate CK level in the absence of underlying neuromuscular disease Elevated … Mastaglia FL, Phillips BA. Oddis CV. These diseases include polymyositis and dermatomyositis, as well as myositis associated with neoplastic disease, myositis associated with underlying collagen-vascular disease, and inclusion body myositis. However, many patients with inclusion body myositis may have asymmetrical weakness or weakness and atrophy of the distal muscle groups, providing a mixed picture. When elevated CK levels are found in a blood sample, it usually means muscle is being destroyed by some abnormal process, such as a muscular dystrophy or inflammation. Most people enjoy a salty snack now and then, but not all salty snacks are healthy. N Engl J Med. In Duchenne and Becker muscular dystrophy, CK levels are typically elevated from the newborn period, prior to clinical presentation. Biopsy also may help with diagnosis of other myopathies, for which different treatment modalities would be required. 1986;13:349-355. A variety of diseases and conditions can cause high muscle enzyme levels. The erythrocyte sedimentation rate and C-reactive protein level often are normal in patients with myositis and therefore are not diagnostically helpful. It’s transported to your muscles where it’s used for energy. Along with your medicines and other treatments, ask your healthcare provider whether the following lifestyle changes are appropriate for you. Although dermatomyositis can be seen in both adults and children, polymyositis is seen almost exclusively in adults. Idiopathic inflammatory myopathies: epidemiology, classification, and diagnostic criteria. Imaging MRI is the most useful imaging modality for diagnosis and monitoring of myositis. CPK is also found in brain cells. There are a number of possible reasons why the patient experiences elevated CK levels. Normally, there is very little creatine kinase found in the blood; elevated … Laboratory testing Although serum elevations of aldolase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase can be seen in myopathic disease, elevation of the creatine kinase (CK) level is thought to be the most sensitive laboratory test result related to skeletal muscle damage. High creatine kinase may indicate that you have a serious medical condition. Severe disease may be seen with minimal elevations as well as with very high levels. Background. A serious medical condition called rhabdomyolysis can occur at 1,000 IU/L. Then, creatinine level will increase. What is a creatine kinase (CK) test? However, muscle weakness is a common symptom in many patients with other conditions, and the differential diagnosis for the complaint is extensive (Table 2). It is mostly found in your skeletal muscles and heart, with lesser amounts in the brain. In addition, the physician must look for signs of neoplastic or other connective-tissue diseases. To compare the pathogenesis and the clinical features of rhabdomyolysis and neuroleptic malignant syndrome. Creatine kinase, or CK shortly , is actually a type of enzyme found within your muscles. My lab test shows creatine level is 1.1 and albumin is trace.Does I have any kidney problem?. Otherwise, the patient should engage in regular aerobic and resistance exercise. Given individual differences, doctors recommend taking action if your creatine kinase levels exceed 300 IU/L. Otherwise, values of up to 20,000 IU/L may be tolerated without untoward event. Choy EH, Hoogendijk JE, Lecky B, Winer JB. Don’t take supplements containing creatine, 4. Typically, the dose is 1 mg/kg/day, either as a single dose or in divided doses. Fiber can be found in many foods, including: Dehydration can raise creatinine levels. (particularly when the heart was found to be fine) Answer. Kroll M, Otis J, Kagen L. Serum enzyme, myoglobin and muscle strength relationships in polymyositis and dermatomyositis. What diseases would produce high ck levels? Low creatine kinase causes. Creatinine consists of serum creatinine and urine creatinine and it often refers to serum creatinine which is an important indicator to reflect kidney functions for CKD patients. Inclusion body myositis also is the most common idiopathic inflammatory myopathy. 2 In this case, a rise in CK levels occurred after 12 months of clozapine and 10 months of adjunctive treatment with ziprasidone. Abnormal creatinine levels may be a sign of kidney disease. All rights reserved. Any clinical condition which results in the disruption of the cell membrane of CPK-rich tissues due to injury or lack of oxygen supply causes the release of creatinine phosphokinase (CPK) into systemic circulation. Inflammation in dermatomyositis is predominantly perivascular and consists of CD4+ helper T cells, plasmacytoid dendritic cells, and B lymphocytes. Health Effects of High Creatine Kinase Level 1) May Be Linked to Lower Inflammation. Medicine (Baltimore). In severe cases that require hospitalization, intravenous methylprednisolone may be used. Thromboses of capillaries are also seen. Polymyositis and dermatomyositis are more common in women; inclusion body myositis is 3 times more common in men. Elevated serum creatine kinase levels in psychiatric practice: differential diagnosis and clinical significance: A brief, practical guideline for clinicians. Myoglobin can also be measured in samples of urine. Literature has suggested that CK levels could rise in a period from 5 days to 2 years after initiation of antipsychotic treatment. Monitor cardiac function. Very high CK levels are seen in rhabdomyolysis. Electromyographic (EMG) changes in the idiopathic inflammatory myopathies include the characteristic triad of (1) increased insertional activity, fibrillations, and sharp positive waves; (2) spontaneous, bizarre high-frequency discharges; and (3) polyphasic motor unit potentials of low amplitude and short duration.2 Although this triad is seen in 40% of patients with idiopathic inflammatory myopathies, 10% to 15% of patients will have normal EMG results.8 In patients with inclusion body myositis and distal or asymmetrical weakness, an EMG also may reveal some neuropathic changes. Prednisone is the first-line treatment of choice for polymyositis. When these cells are damaged for any reason, the CPK is released into the blood and can be measured by a blood test. A study with over 12,000 people found that higher CK was linked to lower hs-CRP, which is a measure of chronic inflammation . 2 In this case, a rise in CK levels occurred after 12 months of clozapine and 10 months of adjunctive treatment … Dr. Ed Friedlander answered. Perifascicular atrophy is virtually diagnostic of dermatomyositis, regardless of whether inflammation is present. 1. Elevated CK Enzyme Causes And Treatment. Although several sets of criteria have been developed to more accurately classify these diseases, none of them have been validated.2-4. In examples of rhabdomyolysis (clinically diagnosed muscle damage) CK levels have been found at 10,000–200,000 U/L and as high as 3 × 1 0 6 U/L . Gottron papules are pink or violaceous papular lesions that can be found symmetrically on the dorsal aspects of the distal interphalangeal joints, elbows, patellae, and malleoli (Figure 1). Extraocular muscles are spared. When damage is done to these types of tissue CK is released into the blood. All rights reserved. Some studies have shown that moderate alcohol consumption may help decrease the risk of chronic kidney disease. This article examines the research and…, Sprouted nuts are raw nuts that have been soaked in water in order to germinate, or begin to sprout. Sample requirements. Myopathy associated with malignancy is more common in persons older than 50 years; myopathy associated with collagen-vascular disease occurs at the age that is associated with the particular collagen-vascular disease that is present. Very high creatine kinase levels. Influenza … The most common cancers are those that occur most often in patients of a particular age and sex, with the exception of ovarian cancer, which is overexpressed.9. Creatine kinase is an enzyme (a protein that facilitates chemical reactions in the body) also in the muscle cells. Immunosuppressant and immunomodulatory treatment for dermatomyositis and polymyositis. Rhabdomyolysis is a condition in which damaged skeletal muscle breaks down rapidly. Monitor creatine kinase (CK) levels to show resolution of rhabdomyolysis.