Winkelmann RR, Del Rosso J  K, Improvement seen in both groups at weeks 6 and 12 but no significant intergroup difference. Polypodium leucotomos extract: a status report on clinical efficacy and safety. of literature found orally taking Polypodium leucotomos can treat melasma. Choasma; antioxidant; fern plant extract; photoprotection; pigmentation. Terms of Use| Frena el envejecimiento prematuro de la piel (anti-radicales libres). Conflict of Interest Disclosures: None reported. Research on the health benefits of Polypodium leucotomos is limited to animal and test-tube studies, and small clinical trials. Would you like email updates of new search results? Traditional Asian Herbs in Skin Whitening: The Current Development and Limitations. It should also be taken prior to and during sunny vacations. Critical revision of the manuscript for important intellectual content: Ahmed, Hynan, Chong, Pandya. FOIA  LM, Silva Results: Following four, eight, and 12 weeks of treatment, there were statistically significant differences between the mMASI scores of both groups as compared with the baseline scores (p≤0.01). Taking oral Polypodium leucotomos may … The MelasQOL scores (data not shown) showed minimal change in either group. From evaluation of the placebo group, we conclude that once-daily use of topical, broad-spectrum sunscreen for 12 weeks results in a 14% improvement in the darkness component of melasma. JAMA Dermatol . Sunscreen was donated by Aveeno, Johnson & Johnson Consumer Companies Inc. Role of the Sponsors: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of data; or in the preparation, review, or approval of the manuscript. FUNDING:This study was sponsored by Industrial Farmacéutica Cantabria (IFC), SA. A prospective, randomized, split-face, controlled trial of salicylic acid peels in the treatment of melasma in Latin American women. Estudos revelam uma redução do impacto dos raios UV contra as células da pele, preservando os fibroblastos e mantendo sua capacidade de produzir colágeno. However, there is evidence to suggest it may have antioxidant and anti-inflammatory properties that are helpful for treating certain skin conditions. 8600 Rockville Pike J Eur Acad Dermatol Venereol. Introduction: Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern Polypodium leucotomos (PLE), Fernblock ® (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. Polypodium leucotomos The extract that comes from P. leucotomos has antioxidant and photoprotective qualities, both of which are important for helping fade dark patches of skin. Oli-Ola 150mg + Picnogenol 150mg + Polypodium 150mg | Fórmula exclusiva forte para Manchas e Melasma Oli-Ola é um extrato 100% natural, extraído exclusivamente do fruto da oliveira, padronizado em 3% hidroxitirosol e certificado pelo Ecocert. Polypodium leucotomos in patients with melasma. Shihab N, Prihartono J, Tovar-Garza A, Agustin T, Legiawati L, Pandya AG. Fig. Con propiedades antiinflamatorias, estimulante cerebral, fotoprotector, cicatrizante, antioxidante, inmunomodulador, y también actividad antitumoral asociada, previene el fotoenvejecimiento, protector del ADN celular. Please enable it to take advantage of the complete set of features! A randomized, double-blinded, placebo-controlled trial of oral Polypodium leucotomos extract as an adjunct to sunscreen in the treatment of melasma. A randomized, double-blinded, placebo-controlled trial of oral Polypodium leucotomos extract as an adjunct to sunscreen in the treatment of melasma. Rendon Corresponding Author: Ammar M. Ahmed, MD, Department of Dermatology, University of Texas Southwestern Medical Center at Austin, CEC C2.443, Austin, TX 78701 (amahmed@seton.org). Polypodium leucotomos extract is marketed as a dietary supplement containing a combination of the antioxidants (Heliocare®, Antioxidine®, and others). 2021 Feb;35(2):502-508. doi: 10.1111/jdv.16896. Privacy Policy| Polypodium Leucotomos is a fern, also known as Calaguala used by the natives of northern Honduras as a treatment against malignant tumors Used in Spain and Central America for the treatment of psoriasis, atopic Protege frente a la radiación solar mediante la activación de los mecanismos de defensa naturales de la piel. Author Contributions: Dr Ahmed had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), Subscribe to the JAMA Dermatology journal, FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, US Burden of Neurological Disease, 1990-2017, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles. JAMA Dermatol 2013;149:981-3. …  LF, Brunstein Australas J Dermatol. 2013;149(8): 981–983. Polypodium leucotomos There has been much interest recently in the use of Polypodium leucotomos (PL) as an adjunct photoprotective agent in melasma.  M.  Treatment of melasma. All assessments were performed by blinded investigators. Epub 2020 Feb 28. Epub 2020 Sep 28. A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral Polypodium leucotomos Extract as an Adjunct to Sunscreen in the Treatment of Melasma. The study protocol was approved by our university institutional review board. Accessibility Statement, Our website uses cookies to enhance your experience. There was no significant difference between the 2 groups regarding age, duration of melasma, or Fitzpatrick skin type. For our treatment group, we estimated the mean (SD) improvement in the melanin index compared with that in those receiving placebo to be 11.7 (13.0) points, based on the reported findings of Kodali et al.4 A sample size of 20 patients per study arm was required to detect this difference, assuming a type I error of 0.05 and 80% power, using a 2-sided, 2–independent sample t test. mMASI scores of the PLE group at eight and 12 weeks were also significantly lower than those of the placebo group (p≤0.05). Int J Dermatol. Prevention and treatment information (HHS). Adverse events were recorded. POLYPODIUM EN LA PREVENCION DE LOS … Epub 2020 Aug 31. COVID-19 is an emerging, rapidly evolving situation. The scores of the melanin and erythema indices displayed a slight improvement in both groups, without significant differences among them. 2021 Feb;20(2):532-537. doi: 10.1111/jocd.13803. 2013;149(8):981–983. Subjects were required to have a diagnosis of moderate to severe facial melasma, defined as a melanin index of 30 or greater. Our results demonstrate that the PLE aqueous extract product significantly improves and accelerates the outcome reached with hydroquinone and sunscreen almost from the first month of treatment in comparison with the placebo. Epub 2020 Nov 18. French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial. ANCOVA indicates analysis of covariance; ANOVA, analysis of variance; PLE, Polypodium leucotomos extract. All Rights Reserved. Mexameter (Courage and Khazaka Inc) Results, Figure 2. Haddad In many studies, Polypodium leucotomos extract appears to have a beneficial effect on melasma.  Jr.  A clinical, prospective, randomized, double-blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasma. A randomized, double-blinded, placebo-controlled trial of oral Polypodium leucotomos extract as an adjunct to sunscreen in the treatment of melasma. Trial Registration: clinicaltrials.gov Identifier: NCT01092884. © 2021 American Medical Association. We assessed the effectiveness of Polypodium leucotomos extract (PLE), an oral, commercially available UV radiation protectant, as an adjunct to once-daily topical sunscreen application in the treatment of melasma. New oral and topical approaches for the treatment of melasma. Lima PB, Dias JAF, Cassiano D, Esposito ACC, Bagatin E, Miot LDB, Miot HA. Treatments for melasma include photoprotection in conjunction with topical agents such as hydroquinone, retinoids, or combinations. The results of our study do not support the premise that oral PLE is effective as an adjunct to topical sunscreen in the treatment of melasma in Hispanic women. Both groups tolerated the treatments well. One study found that patients treated with oral P. leucotomos for 12 weeks reported improvements in both MASI (Melasma Area and Severity Index) score and appearance of melasma (Nestor). Drs.  F, Ferreira Assessment of melasma area and severity index (MASI) and melasma-related quality-of-life (MelasQOL) were performed as secondary end points. Pregnant and lactating subjects and those who recently used other treatments for melasma were excluded. MelasQoL score showed an improvement in the PLE group versus the placebo group. Polypodium leucotomos é indicado para fotoproteção de uso oral, auxiliar no tratamento de demência senil, do tipo Mal de Alzheimer ou deterioração mental, psoríase, dermatites e previne o fotoenvelhecimento. Acción Antioxidante y Fotoprotectora. Os europeus empregavam o extrato de Polypodium leucotomos como elemento de um programa global de … The underground "runners" (rhizomes) of the plant are used for medicine. Edemi evidenti, talvolta balloniformi, molto più subdole, e alla lunga pericolose, risult… However, researchers don’t include a recommended dosage. Eritema; 2.  IL, Carrigan Polypodium leucotomos AÇÃO E INDICAÇÃO: Extrato de Polypodium leucotomos administrado por via oral diminui a fototoxicid Pague em até 6 x s/juros, … Conclusão: O levantamento da literatura permitiu concluir que entre as várias propriedades do Polypodium leucotomos ha destaque para a capacidade antioxidante, anti-inflamatória, fotoprotetora e imunomoduladora, possuindo um considerável impacto na melhora da qualidade de vida dos portadores de melasma, sendo um fator clareador e protetor na doença. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients.