They can also go up after drinking too much alcohol or from taking certain medicines or supplements. CK is made up of 3 enzyme forms. This usually reflects an impaired kidney function — but not always. The creatine kinase levels of women and men respond similarly to exercise, but they return to baseline more quickly in women. Other causes are alcohol, viruses, hereditary conditions. Second, it might direct you to the cause of the elevated CK. A 2017 paper in Antioxidants documented this effect during a test known to increase creatine kinase production — downhill running in adult subjects. Gender differences affect creatine kinase levels as well. These are CK-MB, CK-MM, and CK-BB. … One of the most common reasons your doctor might call you for an abnormal blood test result is high creatinine levels. Increase In Creatine Kinase (CK) Levels. Biological relevance. Rhabdomyolysis was defined by a serum CK level of more than 1,000 U/L (more than fivefold that of normal). Recent findings The list of drugs and inciting agents that cause rhabdomyolysis is quite extensive. CK levels were compared by two-tailed Student's t test. This article reviews the pathophysiology, clinical presentations, and common compounds that cause drug-induced rhabdomyolysis. Levels of CK can rise after a heart attack, skeletal muscle injury, or strenuous exercise. The degree of CK elevation varies to a marked level depending upon individual cases. In normal adult, CK activity is almost entirely due to CK-MM isoform. Patients with a CK level of more than 800 U/L had additional tests, including a urine myoglobin, urine drug screen, and serum phosphorus. Finally CPK can be elevated in certain autoimmune diseases that cause inflammation in the muscle such as polymyositis or dermatomyositis. Some medications falsely elevate creatinine and may cause you to … Statins, or 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors, can cause a variety of muscle disorders ranging from asymptomatic hyperCKemia to rhabdomyolysis; occurrence is more common in people with genetic polymorphisms predisposing them to metabolic muscle disease. Serum creatinine (a blood measurement) is an important indicator of kidney health because it is an easily measured byproduct of muscle metabolism that is excreted unchanged by the kidneys. High activity with high CK-MB fraction is predominantly associated with myocardial damage. The muscle cells in your body need CK to function. CK levels may be increased in a wide variety of conditions that affect the brain, including bacterial meningitis, encephalitis, cerebrovascular accidents, hepatic coma, uremic coma, and grand mal epileptic attacks. Muscle damage will increase total CK with usually <6% being of CK-MB type. Creatinine levels can also rise temporarily from strenuous exercise or using certain medications like sulfamethoxazole, trimethoprim, or chemotherapy drugs. Certain drugs such as cholesterol lowering drugs (statins) can damage muscle and elevate CPK. CK activity is greatest in skeletal muscle, 3 times that of cardiac muscle and brain. CK is a type of protein. Drug-induced rhabdomyolysis is a common syndrome that is complex and potentially life threatening.